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Female Speaker : Among the probiotics is the Bacillus family, rod-shaped bacteria found in soil and water, and often on human skin. Within the Bacillus family, we find Bacillus clausii, the probiotic contained in Enterogermina, on which [0:20] much research has been performed to demonstrate its clinical benefits. In clinical trials, Enterogermina has been shown to prevent and treat symptoms resulting from an unbalanced gut microbiome, such as diarrhea and abdominal pain.

Enterogermina's Bacillus clausii has [0:40] very unique properties making it a special probiotic diarrhea medicine. One of them includes its ability to be in spore form which allows it to survive extreme environmental conditions that would otherwise be lethal in its active form, known as the vegetative form. This dormant spore format enables [1:00] Enterogermina Bacillus clausii to pass the gastric barrier and reach the gut without harm, unlike some other probiotics.

These acidic conditions in fact aid the 'activation' of the spores and subsequent germination into their vegetative form once arriving in the gut so that their beneficial effects [1:20] can be conveyed.

Enterogermina probiotic is also special among bacterial probiotics for diarrhea due to its wide antibiotic resistance spectrum. But why is this important? Once under antibiotic therapy, antibiotics attack not only pathogenic bacteria [1:40] causing the infection they should cure, but also the intestinal flora, damaging it and causing undesired gut-related side effects, such as stomach pain and diarrhea.

On these occasions, it is important to rely on a probiotic that can prevent or treat these side effects, [2:00] ensuring it is not 'damaged' itself. In Enterogermina, each of the four Bacillus clausii strains—SIN, T, O/C and N/R— carries with it a specific [2:20] and distinct resistance profile. This smart strain combination means that Enterogermina can be taken together with the most commonly used antibiotics, guaranteeing the survival of a sufficient number of vegetative form spores to deliver its beneficial effects. Therefore, [2:40] when taken together with antibiotics,

Enterogermina is able to prevent antibiotic-associated side effects such as diarrhea and tummy ache and facilitate a high patient compliance to antibiotic therapy. This advantageous quality of antibiotic resistance has been produced by spontaneous [3:00] chromosomal mutations and selection of the strains depending on the antibiotic considered. These mutations are very stable, ensuring a predictable and sustained antibiotic-resistant spectrum. There is also no risk of transfer to other bacteria [3:20] or pathogens as the resistance is encoded in the chromosome and not in the transferable plasmids.